Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism

Zebrafish (ZF; <i>Danio rerio</i>) larvae have become a popular in vivo model in drug metabolism studies. Here, we investigated the metabolism of methyl 2-[1-(4-fluorobutyl)-1<i>H</i>-indazole-3-carboxamido]-3,3-dimethylbutanoate (4F-MDMB-BINACA) in ZF larvae after direct administration of the canna...

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Auteurs principaux:	Yu Mi Park, Charlotte Dahlem, Markus R. Meyer, Alexandra K. Kiemer, Rolf Müller, Jennifer Herrmann
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-02-01
Collection:	Molecules
Sujets:	zebrafish larvae model drug metabolism cannabinoid receptors (CB1 and CB2) mass spectrometry imaging (MSI) hepatotoxicity microinjection
Accès en ligne:	https://www.mdpi.com/1420-3049/27/4/1290
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