Divergence of Primary Cognate B- and T-Cell Proliferative Responses to Subcutaneous and Intravenous Immunization with Virus-Like Particles

A major advantage of virus-like particle (VLP) vaccines against HIV is their structural identity to wild-type viruses, ensuring that antigen-specific B-cells encounter the envelope protein in its natural conformation. For the induction of affinity-matured antibodies, the B-cells must also obtain he...

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Autors principals:	Vladimir Temchura, Svetlana Kalinin, Ghulam Nabi, Bettina Tippler, Thomas Niezold, Klaus Überla
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2014-08-01
Col·lecció:	Viruses
Matèries:	lentiviral VLP B-cell proliferation T-cell proliferation
Accés en línia:	http://www.mdpi.com/1999-4915/6/8/3334
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