A functional overlap between actively transcribed genes and chromatin insulator elements

Abstract The mammalian genome is organised into large topologically associating domains (TADs) and smaller sub-TADs or enhancer-promoter loops, which may contribute to the regulation of gene expression. These dynamic structures arise, at least partly, via cohesin-mediated loop extrusion delimited by...

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Bibliografski detalji

Glavni autori:	Lucy J Cornell, Caroline L Harrold, Susannah Holliman, Felice Tsang, Matthew E Gosden, Lars L P Hanssen, Rosa Stolper, Damien J Downes, Daniel Biggs, Chris Preece, Samy Alghadban, Jacqueline A Sharpe, Benjamin Davies, Jacqueline A Sloane-Stanley, Jim R Hughes, Douglas R Higgs, Mira T Kassouf
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2026-03-01
Serija:	The EMBO Journal
Teme:	CTCF Domains Insulators Regulation Transcription
Online pristup:	https://doi.org/10.1038/s44318-026-00730-2
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