Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common familial form of stroke, which is caused by mutations located in the epidermal growth factor (EGF)-like repeats of the NOTCH3 gene. Mutations cause the NOTCH3 (N3) protein to misfo...

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Auteurs principaux:	Daniel V. Oliveira, Julia Svensson, Xueying Zhong, Henrik Biverstål, Gefei Chen, Helena Karlström
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-02-01
Collection:	Frontiers in Molecular Biosciences
Sujets:	BRICHOS inhibits NOTCH3 aggregation CADASIL Notch3 misfolded protein BRICHOS VSMC = vascular SMC
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.812808/full
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