Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common familial form of stroke, which is caused by mutations located in the epidermal growth factor (EGF)-like repeats of the NOTCH3 gene. Mutations cause the NOTCH3 (N3) protein to misfo...

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Autors principals:	Daniel V. Oliveira, Julia Svensson, Xueying Zhong, Henrik Biverstål, Gefei Chen, Helena Karlström
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-02-01
Col·lecció:	Frontiers in Molecular Biosciences
Matèries:	BRICHOS inhibits NOTCH3 aggregation CADASIL Notch3 misfolded protein BRICHOS VSMC = vascular SMC
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.812808/full
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