Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.
Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability. Claudin-4 was the first claudin whose involvement in the TJ permeability i...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Public Library of Science (PLoS)
2017-01-01
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| Schriftenreihe: | PLoS ONE |
| Online-Zugang: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182521&type=printable |
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