Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

ABSTRACT Bispecific T cell engagers (BTEs) induce MHC‐independent cytotoxicity by bridging T cells to tumor cells via binding a T cell–activating receptor and a tumor‐associated antigen. BTEs have proven effective in hematologic malignancies and some solid tumors, yet their potential in glioblastoma...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-06-01
coleção:	Advanced Science
Assuntos:	brain BTE glioblastoma IL13RA2 immunotherapy metastases
Acesso em linha:	https://doi.org/10.1002/advs.202522391
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!