IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas

Abstract Pediatric high-grade gliomas (pHGG) and pediatric diffuse midline gliomas (pDMG) are devastating diseases without durable and curative options. Although targeted immunotherapy has shown promise, the field lacks immunocompetent animal models to study these processes in detail. To achieve thi...

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Bibliografiska uppgifter

Huvudupphov:	M. Seblani, M. Zannikou, J. T. Duffy, T. Joshi, R. N. Levine, A. Thakur, M. Puigdelloses-Vallcorba, C. M. Horbinski, J. Miska, D. Hambardzumyan, O. J. Becher, Irina V. Balyasnikova
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-04-01
Serie:	Acta Neuropathologica Communications
Länkar:	https://doi.org/10.1186/s40478-025-01991-4
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