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Sleep is bi-directionally modified by amyloid beta oligomers

Disrupted sleep is a major feature of Alzheimer’s disease (AD), often arising years before symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of amyloid-beta (Aβ) species, a major driver of AD progression, suggesting that sleep loss further accelerates AD through a vicio...

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Principais autores: Güliz Gürel Özcan, Sumi Lim, Patricia LA Leighton, W Ted Allison, Jason Rihel
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications Ltd 2020-07-01
סדרה:eLife
נושאים:
sleep
alzheimer's disease
amyloid beta
behavior
prion protein
גישה מקוונת:https://elifesciences.org/articles/53995
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