Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance

Summary: Amyloid precursor protein (APP) is a brain-rich, single pass transmembrane protein that is proteolytically processed into multiple products, including amyloid-beta (Aβ), a major driver of Alzheimer disease (AD). Although both overexpression of APP and exogenously delivered Aβ lead to change...

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Autors principals:	Güliz Gürel Özcan, Sumi Lim, Thomas Canning, Lavitasha Tirathdas, Joshua Donnelly, Tanushree Kundu, Jason Rihel
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-02-01
Col·lecció:	iScience
Matèries:	Biological sciences Molecular genetics Molecular neuroscience
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2589004224000919
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