Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation

Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction, focusing on structural modifications within the aromatic bridge connecting two estradiol moiet...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Jiří Řehulka, Michal Jurášek, Pavel Dráber, Aleksandra Ivanová, Soňa Gurská, Kateřina Ječmeňová, Olena Mokshyna, Marián Hajdúch, Pavel Polishchuk, Pavel B. Drašar, Petr Džubák
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Taylor & Francis Group 2024-12-01
Serie:	Journal of Enzyme Inhibition and Medicinal Chemistry
Ämnen:	Estradiol dimer tubulin cancer cell in silico
Länkar:	https://www.tandfonline.com/doi/10.1080/14756366.2024.2367139
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!