Pharmacological blockade of rho kinase enhances venetoclax responses in translational models of acute myeloid leukemia

Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy requiring concomitant targeting of critical cellular survival pathways due to resistance and frequent relapse with monotherapies. Venetoclax (VEN), a BCL-2 inhibitor, is one such promising clinical agent best utilized in combinati...

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Hauptverfasser:	Upendarrao Golla, Riya Bhalodia, Charyguly Annageldiyev, Satyam Patel, Vishnu Sravan Bollu, Su-Fern Tan, Myles C. Cabot, David J. Feith, Thomas P. Loughran Jr., Ross L. Levine, Shin Mineishi, Hong Zheng, Kentaro Minagawa, Jeremy Hengst, Giselle L. Saulnier Sholler, Dhimant Desai, Sinisa Dovat, Kelsey H. Fisher-Wellman, David F. Claxton, Arati Sharma
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Ferrata Storti Foundation 2026-04-01
Schriftenreihe:	Haematologica
Online-Zugang:	https://haematologica.org/article/view/13431
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