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Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor

Aldehyde dehydrogenases (ALDHs) are a family of enzymes that aid in detoxification and are overexpressed in several different malignancies. There is a correlation between increased expression of ALDH and a poor prognosis, stemness, and resistance to several drugs. Several ALDH inhibitors have been g...

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Principais autores: Krishne Gowda, Asif Raza, Venugopal Vangala, Nazir Ahmad Lone, Jyh Ming Lin, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Todd D. Schell, Gavin P. Robertson, Shantu Amin, Arun K. Sharma
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-06-01
coleção:Molecules
Assuntos:
chemical synthesis
aldehyde dehydrogenases
cancer therapeutics
colon cancer
ovarian cancer
pancreatic cancer
Acesso em linha:https://www.mdpi.com/1420-3049/29/13/3114
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