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Effects of Chirality on the Antifungal Potency of Methylated Succinimides Obtained by Aspergillus fumigatus Biotransformations. Comparison with Racemic Ones

Eighteen (3R) and (3R,4R)-N-phenyl-, N-phenylalkyl and N-arylsuccinimides were prepared with high enantioselectivity by biotransformation of maleimides with A. fumigatus. This environmentally friendly, clean and economical procedure was performed by the whole-cell fungal bioconversion methodology. T...

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Principais autores: Susana Zacchino, Agustina Postigo, Maximiliano Sortino
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2013-05-01
Serier:Molecules
Fag:
biotransformation
Aspergillus fumigatus
enantioselective reduction
enhanced antifungal activity
chiral succinimides
methylated succinimides
Online adgang:http://www.mdpi.com/1420-3049/18/5/5669
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