Effects of Chirality on the Antifungal Potency of Methylated Succinimides Obtained by Aspergillus fumigatus Biotransformations. Comparison with Racemic Ones

Eighteen (3R) and (3R,4R)-N-phenyl-, N-phenylalkyl and N-arylsuccinimides were prepared with high enantioselectivity by biotransformation of maleimides with A. fumigatus. This environmentally friendly, clean and economical procedure was performed by the whole-cell fungal bioconversion methodology. T...

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Autori principali:	Susana Zacchino, Agustina Postigo, Maximiliano Sortino
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2013-05-01
Serie:	Molecules
Soggetti:	biotransformation Aspergillus fumigatus enantioselective reduction enhanced antifungal activity chiral succinimides methylated succinimides
Accesso online:	http://www.mdpi.com/1420-3049/18/5/5669
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