A Review on Fused Pyrimidine Systems as EGFR Inhibitors and Their Structure–Activity Relationship
Epidermal growth factor receptor (EGFR) belongs to the family of tyrosine kinase that is activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular proliferation process, differentiation, and apoptosis. In the case of cancer, EGFR undergoes uncontrolled auto-phosphoryl...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2022-06-01
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| Schriftenreihe: | Frontiers in Chemistry |
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| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fchem.2022.861288/full |
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