In Vitro Anticancer Activity Screening of Novel Fused Thiophene Derivatives as VEGFR-2/AKT Dual Inhibitors and Apoptosis Inducers

Protein kinases are seen as promising targets in controlling cell proliferation and survival in treating cancer where fused thiophene synthon was utilized in many kinase inhibitors approved by the FDA. Accordingly, this work focused on adopting fused thienopyrrole and pyrrolothienopyrimidine scaffol...

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Bibliografski detalji

Glavni autori:	Rana M. Abdelnaby, Afaf A. El-Malah, Rasha R. FakhrEldeen, Marwa M. Saeed, Rania I. Nadeem, Nancy S. Younis, Hanaa M. Abdel-Rahman, Nehad M. El-Dydamony
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2022-06-01
Serija:	Pharmaceuticals
Teme:	anticancer apoptosis thiophene thienopyrimidine VEGFR-2 AKT
Online pristup:	https://www.mdpi.com/1424-8247/15/6/700
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