KLHDC3 deficiency in mice reveals essential roles in development, survival, and adiposity via the DesCEND ubiquitin pathway

Abstract Background Protein ubiquitination is a key post-translational modification that governs protein stability and cellular homeostasis. KLHDC3 is a substrate recognition receptor in the recently identified C-terminal degron-mediated DesCEND ubiquitination pathway. It selectively binds proteins...

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Bibliografische gegevens

Hoofdauteurs:	Paula Armina V. Buco, Ashfaqul Hoque, Wilson Castillo-Tandazo, Alistair M. Chalk, Monique F. Smeets, Carl R. Walkley
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2026-01-01
Reeks:	BMC Genomics
Onderwerpen:	KLHDC3 DesCEND pathway E3 ubiquitin ligase Ubiquitylation Adipogenesis Obesity
Online toegang:	https://doi.org/10.1186/s12864-026-12574-5
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