α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice

Abstract Background In heart failure (HF), mitochondrial dysfunction and metabolic remodeling lead to a reduction in energy productivity and aggravate cardiomyocyte injury. Supplementation with α-ketoglutarate (AKG) alleviated myocardial hypertrophy and fibrosis in mice with HF and improved cardiac...

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Váldodahkkit:	Hao Yu, Daojing Gan, Zhen Luo, Qilin Yang, Dongqi An, Hao Zhang, Yingchun Hu, Zhuang Ma, Qingchun Zeng, Dingli Xu, Hao Ren
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2024-01-01
Ráidu:	Molecular Medicine
Fáttát:	α-Ketoglutarate Cardiac insufficiency Mitophagy Ferroptosis Transverse aortic constriction Angiotensin II
Liŋkkat:	https://doi.org/10.1186/s10020-024-00783-1
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