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Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN/HOCL/ERK signaling pathways

Abstract Abdominal aortic aneurysm (AAA) represents the serious vascular degenerative disorder, which causes high incidence and mortality. Alpha-ketoglutarate (AKG), a crucial metabolite in the tricarboxylic acid (TCA) cycle, has been reported to exert significant actions on the oxidative stress and...

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Principais autores: Junjun Liu, Mingyuan Liu, Jiaxuan Feng, Hongqiao Zhu, Jianlie Wu, Heng Zhang, Shun Xiao, Zaiping Jing, Jian Zhou, Haitao Niu, Mingjin Guo
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-10-01
Serier:Journal of Translational Medicine
Fag:
Abdominal aortic aneurysm
Alpha-ketoglutarate
ROS
PXDN
HOCL
ERK1/2
Online adgang:https://doi.org/10.1186/s12967-022-03659-2
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