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Is Desmin Propensity to Aggregate Part of its Protective Function?

Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF). These desmin alterations are reversed by therapy, suggesting a causal role for the...

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Bibliografiske detaljer
Principais autores: Sonia R. Singh, Hikmet Kadioglu, Krishna Patel, Lucie Carrier, Giulio Agnetti
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-02-01
Serier:Cells
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Online adgang:https://www.mdpi.com/2073-4409/9/2/491
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