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Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats

Alzheimer’s disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell deat...

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Principais autores: Yulia V. Dobryakova, Maria N. Volobueva, Anna O. Manolova, Tatiana M. Medvedeva, Alexey A. Kvichansky, Natalia V. Gulyaeva, Vlamidir A. Markevich, Mikhail Yu. Stepanichev, Alexey P. Bolshakov
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-03-01
coleção:Frontiers in Neuroscience
Assuntos:
192IgG-saporin
dorsal hippocampus
microglia
vascular endothelium
CA3 area
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnins.2019.00146/full
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