Intrahippocampal Adeno-Associated Virus–Mediated Overexpression of Nerve Growth Factor Reverses 192IgG-Saporin–Induced Impairments of Hippocampal Plasticity and Behavior

One of the aspects of Alzheimer disease is loss of cholinergic neurons in the basal forebrain, which leads to development of cognitive impairment. Here, we used a model of cholinergic deficit caused by immunotoxin 192IgG-saporin to study possible beneficial effects of adeno-associated virus (AAV)–me...

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Principais autores:	Yulia V. Dobryakova, Yulia S. Spivak, Maria I. Zaichenko, Alena A. Koryagina, Vladimir A. Markevich, Mikhail Yu. Stepanichev, Alexey P. Bolshakov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-11-01
coleção:	Frontiers in Neuroscience
Assuntos:	nerve growth factor 192IgG-saporin behavior long-term potentiation septum hippocampus
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2021.745050/full
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