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Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals

Abstract Objective The NCoR-1 and NCoR-2 corepressors are products of an early gene duplication near the beginning of vertebrate evolution and play both overlapping and divergent roles in development and physiology. Alternative-splicing of NCoR-1 and NCoR-2 further customizes their functions. To bet...

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Gardado en:
Principais autores: Martin L. Privalsky, Michael L. Goodson
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-06-01
Series:BMC Research Notes
Assuntos:
Alternative mRNA splicing
Evolution
Corepressors
Transcriptional regulation
Nuclear receptors
Nuclear hormone receptors
Acceso en liña:http://link.springer.com/article/10.1186/s13104-019-4384-z
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