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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes

Abstract Aims Aptamer BC 007, a 15‐mer single‐strand DNA oligonucleotide (5'‐GGTTGGTGTGGTTGG‐3'), was developed to neutralize functional autoantibodies that bind to the extracellular domains of G protein‐coupled receptors (GPCR‐AAB), leading to the modulation of receptor‐mediated signalling cascades...

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Principais autores: Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020-06-01
Serier:ESC Heart Failure
Fag:
Anti‐beta1‐adrenergic receptor antibodies
BC 007
Cardiomyopathy
Doberman Pinscher
Heard failure
Treatment
Online adgang:https://doi.org/10.1002/ehf2.12628
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