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PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue

Abstract Beige adipose tissue protects against obesity and related metabolic diseases by catabolizing stored energy to generate heat. While iron is essential for this process due to its role in mitochondrial function, the specific signaling mechanisms involved remain unclear. Here, we report that di...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xue-Min Peng, Rui He, Huan-Yu Wang, Jia-Dai Liu, Yu-Yu Xie, Zhi-Han Wang, Hong-Yan Deng, Wen-She Wang, Zeng-Zhe Zhu, Jing Ge, Yu-Lian Liu, Rong-Hui Gao, Min Yang, Dan-Pei Li, Qian-Qian Kang, Ru-Ping Pan, Yong Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-12-01
Schriftenreihe:Cell Communication and Signaling
Schlagworte:
Iron metabolism
Beige adipocytes
Thermogenesis
Obesity
PSPC1-SMAD3 axis
Online-Zugang:https://doi.org/10.1186/s12964-025-02570-9
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