PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue

Abstract Beige adipose tissue protects against obesity and related metabolic diseases by catabolizing stored energy to generate heat. While iron is essential for this process due to its role in mitochondrial function, the specific signaling mechanisms involved remain unclear. Here, we report that di...

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Detalhes bibliográficos

Principais autores:	Xue-Min Peng, Rui He, Huan-Yu Wang, Jia-Dai Liu, Yu-Yu Xie, Zhi-Han Wang, Hong-Yan Deng, Wen-She Wang, Zeng-Zhe Zhu, Jing Ge, Yu-Lian Liu, Rong-Hui Gao, Min Yang, Dan-Pei Li, Qian-Qian Kang, Ru-Ping Pan, Yong Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
Colecção:	Cell Communication and Signaling
Assuntos:	Iron metabolism Beige adipocytes Thermogenesis Obesity PSPC1-SMAD3 axis
Acesso em linha:	https://doi.org/10.1186/s12964-025-02570-9
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