Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas

IntroductionAdult-type diffuse gliomas are malignant primary brain tumors characterized by very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in cancer, but their role in gliomas remains poorly understood.MethodsIn this study, we characterized tumor-infiltrati...

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Auteurs principaux:	Claudia Carenza, Sara Franzese, Alessandra Castagna, Sara Terzoli, Matteo Simonelli, Pasquale Persico, Lorenzo Bello, Marco Conti Nibali, Federico Pessina, Paolo Kunderfranco, Clelia Peano, Simone Balin, Joanna Mikulak, Francesca Calcaterra, Raffaella Bonecchi, Benedetta Savino, Massimo Locati, Silvia Della Bella, Domenico Mavilio
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-01-01
Collection:	Frontiers in Immunology
Sujets:	dendritic cells brain tumors perioperative corticosteroids immune suppressive tumor microenvironment single cell-RNA sequencing
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1074762/full
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