<i>A First-Class Degrader Candidate Targeting Both</i> KRAS G12D and G12V Mediated by CANDDY Technology Independent of Ubiquitination

“Undruggable” targets such as KRAS are particularly challenging in the development of drugs. We devised a novel chemical knockdown strategy, CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) technology, which promotes protein degradation using small molecules (CANDDY molecules) that...

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Hlavní autoři:	Etsuko Miyamoto-Sato, Satoshi Imanishi, Lijuan Huang, Shoko Itakura, Yoichi Iwasaki, Masamichi Ishizaka
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-07-01
Edice:	Molecules
Témata:	target protein degradation undruggable target KRAS G12D KRAS G12V cancer degrader
On-line přístup:	https://www.mdpi.com/1420-3049/28/14/5600
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