KRAS G12C and KRAS G12D respond to lipid metabolism in an allele-specific manner

KRAS mutated at hotspots G12, G13, and Q61 possess profound allele-specific oncogenesis. Signaling of KRAS mutants is mostly compartmentalized to the proteolipid nanoclusters on the plasma membrane (PM), illustrating critical roles of spatiotemporal organization in KRAS cancer signaling. The activat...

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Detalles Bibliográficos

Autores principales:	Neha Arora, Hong Liang, Walaa Kattan, Wantong Yao, Haoqiang Ying, Junchen Liu, Yong Zhou
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-07-01
Colección:	Journal of Lipid Research
Materias:	KRAS nanoclustering lysophosphatidylcholine acyltransferase 1 phosphatidylserine acyl chains electron microscopy
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0022227526001057
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