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Glutamine-driven upregulation of NPDC1 promotes colorectal cancer progression through PI3K/AKT signaling

Abstract Background Colorectal cancer (CRC) ranks as one of the leading causes of cancer-related mortality globally. NPDC1 is a novel regulator involved in cell proliferation and is upregulated in CRC. However, the biological function and mechanism of NPDC1 driving CRC progression have not been inve...

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Principais autores: Qing Qin, Dapeng Zhang, Yusai Xie, Fan Zhang, Yulan Huang, Renchao Deng, Minli Yang, Lili Zhang, Houjie Liang, Rongchen Shi
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-01-01
Serier:Journal of Translational Medicine
Fag:
Colorectal cancer
NPDC1
KRAS mutation
Glutamine
Online adgang:https://doi.org/10.1186/s12967-026-07733-x
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