A STAT1-GBP1 axis modulates epithelial proliferation in postpartum breast tissue by repressing CDKI expression

Abstract Background Postpartum breast cancer, diagnosed within five years of childbirth, is associated with heightened mortality compared to breast cancers in nulliparous women. Although the postpartum breast undergoes extensive involution and remodeling, the molecular drivers that promote subsequen...

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Detalhes bibliográficos

Principais autores:	Joshua W. Ogony, Laura M. Pacheco-Spann, Amanda Arnold, Jennifer V. Cabezas, Nicole Cruz-Reyes, Camila Pacheco Erak, Pria J. Westerman, Savanna A. Touré, Sharoon Akhtar, Stacey J. Winham, Sarah McLaughlin, Amy C. Degnim, Mark E. Sherman, Derek C. Radisky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-09-01
coleção:	Breast Cancer Research
Assuntos:	Postpartum breast cancer Mammary gland involution STAT1 GBP1 Cyclin-dependent kinase inhibitors (CDKIs) Epithelial proliferation
Acesso em linha:	https://doi.org/10.1186/s13058-025-02117-3
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