Multi‑scale immune and spatial profiling of sclerosing adenosis and surrounding breast tissue identifies an immune‑cold field phenotype associated with breast cancer risk

Abstract Background Benign breast disease (BBD) is common and confers heterogeneous increases in breast cancer risk; however, risk prediction relies mainly on histopathology and clinical factors. Sclerosing adenosis (SA) is a proliferative BBD lesion associated with an approximately two-fold increas...

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Hlavní autoři:	Nicole Cruz-Reyes, Hongling Liang, Melody Stallings-Mann, Laura Pacheco-Spann, Bryan M. McCauley, Yuanhang Liu, Robert A Vierkant, Jessica L. Fischer, Denice L. Gehling, Lisa R. Seymour, Amy C. Degnim, Mark E. Sherman, Stacey J. Winham, Derek C. Radisky
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-05-01
Edice:	Breast Cancer Research
Témata:	Benign breast disease Sclerosing adenosis Breast cancer risk Tumour microenvironment Multiplex immunofluorescence NanoString
On-line přístup:	https://doi.org/10.1186/s13058-026-02293-w
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