Multi‑scale immune and spatial profiling of sclerosing adenosis and surrounding breast tissue identifies an immune‑cold field phenotype associated with breast cancer risk

Abstract Background Benign breast disease (BBD) is common and confers heterogeneous increases in breast cancer risk; however, risk prediction relies mainly on histopathology and clinical factors. Sclerosing adenosis (SA) is a proliferative BBD lesion associated with an approximately two-fold increas...

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Principais autores:	Nicole Cruz-Reyes, Hongling Liang, Melody Stallings-Mann, Laura Pacheco-Spann, Bryan M. McCauley, Yuanhang Liu, Robert A Vierkant, Jessica L. Fischer, Denice L. Gehling, Lisa R. Seymour, Amy C. Degnim, Mark E. Sherman, Stacey J. Winham, Derek C. Radisky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
coleção:	Breast Cancer Research
Assuntos:	Benign breast disease Sclerosing adenosis Breast cancer risk Tumour microenvironment Multiplex immunofluorescence NanoString
Acesso em linha:	https://doi.org/10.1186/s13058-026-02293-w
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