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Distinct genetic architecture of coronary heart disease in dyslipidemia patients

Abstract Background Mutations of LDLR, APOB and PCSK9 have been well-established to cause hypercholesterolemia while the pathogenic effects of LPL has been confirmed by cohorts and functional studies in hypertriglyceridemia. However, these mutations do not fully account for all dyslipidemia, and it...

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Principais autores: Man Huang, Xiuli Song, Shuni Zhou, Haiyan Zhang, Lijuan He, Yanghui Chen, Guangzhi Chen, Hu Ding, Jiangang Jiang, Yan Wang, Dao Wen Wang, Yang Sun, Hong Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-05-01
Serier:BMC Medical Genomics
Fag:
Hypercholesterolemia
Hypertriglyceridemia
Whole exome sequencing
Coronary heart disease
LDLR
APOB
Online adgang:https://doi.org/10.1186/s12920-026-02388-5
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