Xuetongsu attenuates bone destruction in rheumatoid arthritis by suppressing RANKL/RANK/NFATc1 pathway to inhibit osteoclastogenesis and bone resorption

Aims: Bone destruction is a pivotal pathological factor in the development of joint disability in rheumatoid arthritis (RA) patients, and there is a paucity of safe and effective drugs targeting bone destruction. Xuetong (Kadsura heteroclita Roxb), a traditional Tujia medicine with blood-activating...

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Главные авторы:	Hao Zheng, Yasi Deng, Bin Li, Juan Huang, Jinzhi Liu, Yupei Yang, Yuxin Chen, Linxi Mao, Yamei Li, Yuexuan Liu, Wei Wang, Huanghe Yu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	The British Editorial Society of Bone & Joint Surgery 2025-11-01
Серии:	Bone & Joint Research
Предметы:	rheumatoid arthritis bone destruction xuetongsu ‌rankl/rank/nfatc1 pathway osteoclastogenesis bone resorption osteoclasts rats in the model blood swelling arthritis joint inflammation staining
Online-ссылка:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1411.BJR-2025-0259.R1
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