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Xuetongsu attenuates bone destruction in rheumatoid arthritis by suppressing RANKL/RANK/NFATc1 pathway to inhibit osteoclastogenesis and bone resorption

Aims: Bone destruction is a pivotal pathological factor in the development of joint disability in rheumatoid arthritis (RA) patients, and there is a paucity of safe and effective drugs targeting bone destruction. Xuetong (Kadsura heteroclita Roxb), a traditional Tujia medicine with blood-activating...

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Principais autores: Hao Zheng, Yasi Deng, Bin Li, Juan Huang, Jinzhi Liu, Yupei Yang, Yuxin Chen, Linxi Mao, Yamei Li, Yuexuan Liu, Wei Wang, Huanghe Yu
Format: Artigo
Sprog:Inglês
Udgivet: The British Editorial Society of Bone & Joint Surgery 2025-11-01
Serier:Bone & Joint Research
Fag:
rheumatoid arthritis
bone destruction
xuetongsu
‌rankl/rank/nfatc1 pathway
osteoclastogenesis
bone resorption
osteoclasts
rats in the model
blood
swelling
arthritis
joint inflammation
staining
Online adgang:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1411.BJR-2025-0259.R1
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