Structural insights into the atypical filament assembly of pyrin domain-containing IFI16

Abstract In response to various intracellular stress or damage-associated signals, inflammasomes can be activated and trigger a pyroptotic cell death process through the sequential assembly of structurally compatible and interacting filamentous oligomers involving the pyrin domains (PYD) of importan...

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Prif Awduron:	Archit Garg, Ewa Niedzialkowska, Jeffrey J Zhou, Jasper Moh, Edward H Egelman, Jungsan Sohn
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Springer Nature 2025-11-01
Cyfres:	The EMBO Journal
Pynciau:	Interferon-inducible Protein 16 Innate Immune System Inflammasomes Cryo-EM Pyrin Domain
Mynediad Ar-lein:	https://doi.org/10.1038/s44318-025-00626-7
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