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Structural insights into the atypical filament assembly of pyrin domain-containing IFI16

Abstract In response to various intracellular stress or damage-associated signals, inflammasomes can be activated and trigger a pyroptotic cell death process through the sequential assembly of structurally compatible and interacting filamentous oligomers involving the pyrin domains (PYD) of importan...

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Principais autores: Archit Garg, Ewa Niedzialkowska, Jeffrey J Zhou, Jasper Moh, Edward H Egelman, Jungsan Sohn
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2025-11-01
Serier:The EMBO Journal
Fag:
Interferon-inducible Protein 16
Innate Immune System
Inflammasomes
Cryo-EM
Pyrin Domain
Online adgang:https://doi.org/10.1038/s44318-025-00626-7
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