A molecular modeling approach for structure-based virtual screening and identification of novel anti-hypercholesterolemic agents from Grape

Hypercholesterolemia is a potential cardiovascular hazard that requires immediate therapeutic intervention. Research has shown that 3-Hydroxy-3-methylglutaryl- CoA reductase (HMG CoA reductase) and Proprotein convertase subtilisin/kexin type 9 (PCSK9) are directly involved in the pathophysiology of...

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Principais autores:	Precious A. Akinnusi, Samuel O. Olubode, Adebowale A. Alade, Samad A. Ahmed, Susan F. Ayekolu, Taiwo M. Ogunlade, Damilola J. Gbore, Olayemi D. Rotimi, Abigail O. Ayodele
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-01-01
Colecção:	Informatics in Medicine Unlocked
Assuntos:	Hypercholesterolemia LDL HMG-CoA reductase PCSK9 Molecular modeling MMGBSA
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352914822002027
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