GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia

Summary: Activation of prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus (ARC) promotes high-fat-diet (HFD)-induced hyperphagia. In turn, PNOCARC neurons can inhibit the anorexic response of proopiomelanocortin (POMC) neurons. Here, we validate the necessity of PNOCARC activity for H...

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Autors principals:	Tamara Sotelo-Hitschfeld, Marielle Minère, Paul Klemm, Diba Borgmann, Daria Wnuk-Lipinski, Alexander Jais, Xianglian Jia, Svenja Corneliussen, Peter Kloppenburg, Henning Fenselau, Jens Claus Brüning
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-06-01
Col·lecció:	Cell Reports
Matèries:	CP: Neuroscience CP: Metabolism
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124724006715
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