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CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma

Abstract Glioblastomas are the most prevalent and aggressive malignant brain tumors, characterized by hypertranscription and dependence on neurodevelopmental transcription factors. The transcriptional cycle is regulated by phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII)...

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Principais autores: Silje Lier, Sara B Markusson, Anja Kocijancic, Martine Narum, Solveig O Lund, Bianka Böllering, Anuja Lipsa, Mirra L C Søegaard, Idun D Rein, Petra Santha, Preeti Jain, Anna Lång, Emma Lång, Niklas Meyer, Aparajita Dutta, Santosh Anand, Sugith B Badugu, Gaute J Nesse, Rune J Forstrøm, Arne Klungland, Ashish Anand, Steven M Pollard, Stig O Bøe, Johanne E Rinholm, Katrin B M Frauenknecht, Anna Golebiewska, Simone P Niclou, Kumar Somyajit, Mads Lerdrup, Deo P Pandey
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2026-03-01
Serier:EMBO Molecular Medicine
Fag:
Transcriptional Addiction
Transcriptional Cycle
Transcriptional Cyclin-Dependent Kinases (tCDKs)
DNA Replication
Glioblastoma
Online adgang:https://doi.org/10.1038/s44321-026-00393-w
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