Inhibition of GOT1 potentiates ferroptosis and exacerbates cell death in acute myeloid leukemia

Abstract Background Drug resistance, poor treatment response, and low long-term survival rates are major obstacles to the successful long-term treatment of acute myeloid leukemia (AML), a heterogeneous hematologic malignancy. A deeper understanding of the molecular mechanisms underlying AML is there...

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Hauptverfasser:	Huan Peng, Fangshu Liu, Wenjue Tang, Xin Lin, Qiongyou Liang, Qinle Zhang, Huihong Dou, Sheng He
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-03-01
Schriftenreihe:	European Journal of Medical Research
Schlagworte:	Acute myeloid leukemia GOT1 Ferroptosis Multi-omics analysis Therapeutic target
Online-Zugang:	https://doi.org/10.1186/s40001-026-04271-6
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