Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

Abstract Background Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an unconventional metabolic pathway catalyzed by aspartate transaminase 1 (G...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Weiguang Sun, Shanshan Luan, Changxing Qi, Qingyi Tong, Shan Yan, Hua Li, Yonghui Zhang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2019-08-01
Sarja:	Cell Communication and Signaling
Aiheet:	Aspulvinone O Pancreatic ductal adenocarcinoma cells GOT1 inhibitor Glutamine metabolism
Linkit:	http://link.springer.com/article/10.1186/s12964-019-0425-4
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