Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival.

Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that drives growth and suppresses activity of the MiT/T...

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Principais autores:	John T Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J Matkovich, Kerry Kornfeld, Abhinav Diwan
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2019-05-01
Serija:	PLoS Biology
Online dostop:	https://doi.org/10.1371/journal.pbio.3000245
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