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Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy

EphA4 is a receptor of the Eph-ephrin system, which plays an important role in axon guidance during development. Previously, we identified EphA4 as a genetic modifier of amyotrophic lateral sclerosis (ALS) in both zebrafish and rodent models, via modulation of the intrinsic vulnerability, and re-spr...

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Principais autores: Lindsay Poppe, Silke Smolders, Laura Rué, Mieke Timmers, Annette Lenaerts, Annet Storm, Lies Schoonaert, Antina de Boer, Philip Van Damme, Ludo Van Den Bosch, Wim Robberecht, Robin Lemmens
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-11-01
coleção:Frontiers in Neuroscience
Assuntos:
spinal muscular atrophy
EphA4
neuromuscular junction
sprouting
motor neuron
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnins.2019.01233/full
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