Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy

EphA4 is a receptor of the Eph-ephrin system, which plays an important role in axon guidance during development. Previously, we identified EphA4 as a genetic modifier of amyotrophic lateral sclerosis (ALS) in both zebrafish and rodent models, via modulation of the intrinsic vulnerability, and re-spr...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Lindsay Poppe, Silke Smolders, Laura Rué, Mieke Timmers, Annette Lenaerts, Annet Storm, Lies Schoonaert, Antina de Boer, Philip Van Damme, Ludo Van Den Bosch, Wim Robberecht, Robin Lemmens
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2019-11-01
سلاسل:	Frontiers in Neuroscience
الموضوعات:	spinal muscular atrophy EphA4 neuromuscular junction sprouting motor neuron
الوصول للمادة أونلاين:	https://www.frontiersin.org/article/10.3389/fnins.2019.01233/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!