A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
The human genome contains thousands of long noncoding RNAs which have been preserved by evolution, through their functions are poorly described. Here the authors show that NORAD binds the Pumilo homologues PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Portfolio
2016-07-01
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| Schriftenreihe: | Nature Communications |
| Online-Zugang: | https://doi.org/10.1038/ncomms12209 |
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