Phase-targeting rapid cryofixation of the beating heart and histological analysis unveil contractile state-dependent sarcomere dynamics

Abstract The heart is a functional syncytium consisting of numerous cardiomyocytes that repetitively exhibit coordinated contractions/relaxations. However, the extent to which myocyte sarcomere arrangements in the heart differ across beats is unknown. To examine this, we conducted cardiac phase-targ...

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Hlavní autoři:	Shoko Tamura, Kentaro Mochizuki, Yasuaki Kumamoto, Yuma Morishita, Masahito Yamanaka, Wen-Jin Ho, Yoshinori Harada, Katsumasa Fujita, Hideo Tanaka
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-02-01
Edice:	Scientific Reports
Témata:	Heart Cardiac phase Cryofixation Sarcomere length Ventricular fibrillation
On-line přístup:	https://doi.org/10.1038/s41598-026-41756-0
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