Phase-targeting rapid cryofixation of the beating heart and histological analysis unveil contractile state-dependent sarcomere dynamics

Abstract The heart is a functional syncytium consisting of numerous cardiomyocytes that repetitively exhibit coordinated contractions/relaxations. However, the extent to which myocyte sarcomere arrangements in the heart differ across beats is unknown. To examine this, we conducted cardiac phase-targ...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Shoko Tamura, Kentaro Mochizuki, Yasuaki Kumamoto, Yuma Morishita, Masahito Yamanaka, Wen-Jin Ho, Yoshinori Harada, Katsumasa Fujita, Hideo Tanaka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-02-01
coleção:	Scientific Reports
Assuntos:	Heart Cardiac phase Cryofixation Sarcomere length Ventricular fibrillation
Acesso em linha:	https://doi.org/10.1038/s41598-026-41756-0
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!